What is sage?People use sage for several menopausal symptoms including night sweats, hot flashes, and mood swings.One study, reported in Advances in Therapy, found that a fresh sage preparation lowered the severity and the number of hot flashes (also called hot flushes) in menopausal women.Only sage capsules have been studied for menopausal symptoms.There isn’t enough research to know if other sage products work as well or what the best dose might be.Different sage products often recommend different doses.Risks and things to consider Because there are so many different types of sage, it’s important to research the type you take.There are other safety concerns associated with sage: Spanish sage (Salvia lavandulifolia) and other types of sage may mimic the effects of estrogen, making them potentially unsafe for women with hormone-dependent cancers.It’s important to let your doctor know if you’re taking a sage supplement, including tea, especially if you have or are on medication for high or low blood pressure, any type of cancer, or diabetes.The mechanism by which yoga positively affects menopause symptoms isn’t fully understood, but it’s been shown to improve hot flashes and night sweats.A study reported in the Iranian Journal of Nursing and Midwifery Research found that acupressure was more effective than a placebo at reducing hot flashes, night sweats, and anxiety, particularly when combined with conventional medical care.HRT and conventional medicine There are a number of ways that your doctor can help treat menopause symptoms.Herbal remedies are regulated by the Food and Drug Administration (FDA) as dietary supplements, not as medications. .

SAGE: Overview, Uses, Side Effects, Precautions, Interactions

BMJ 1995;311:1472.Petelin A, Kenig S, Kopinc R, Dezelak M, Cernelic Bizjak M, Jenko Praznikar Z.J Ethnopharmacol 9-25-2007;113(3):363-381.Akhondzadeh, S. and Abbasi, S. H.

Herbal medicine in the treatment of Alzheimer's disease.Am J Alzheimers.Dis Other Demen.Int Pharm Fed World Cong 2002;62:135.[Antioxidant properties of plant extracts].Bozin, B., Mimica-Dukic, N., Samojlik, I., and Jovin, E. Antimicrobial and antioxidant properties of rosemary and sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oils.The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease.De, Leo, V, Lanzetta, D., Cazzavacca, R., and Morgante, G. [Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent].Dos Santos-Neto, L.

L., Vilhena Toledo, M. A., Medeiros-Souza, P., and de Souza, G.

A.The use of herbal medicine in Alzheimer's disease-a systematic review.Eidi, M., Eidi, A., and Zamanizadeh, H. Effect of Salvia officinalis L.

leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats.Nutr Cancer 2003;46(1):30-37.Int J Food Microbiol.Basic Clin Pharmacol Toxicol.Horiuchi, K., Shiota, S., Hatano, T., Yoshida, T., Kuroda, T., and Tsuchiya, T. Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE).Drugs Aging 6-1-2011;28(6):439-468.Eur J Med Res 1-31-2006;11(1):20-26.The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta peptide-induced neurotoxicity.B., and Haskell, C. F.

Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults.Kianbakht, S., Abasi, B., Perham, M., and Hashem, Dabaghian F. Antihyperlipidemic effects of Salvia officinalis L. leaf extract in patients with hyperlipidemia: a randomized double-blind placebo-controlled clinical trial.J Agric Food Chem 6-15-2005;53(12):4740-4746.Asia Pac.J Clin Nutr 2006;15(1):107-118.Comparison of benzydamine hydrochloride and Salvia officinalis as an adjuvant local treatment to systemic nonsteroidal anti-inflammatory drug in controlling pain after tonsillectomy, adenoidectomy, or both: An open-label, single-blind, randomized clinical trial.Lima, C. F., Andrade, P. B., Seabra, R. M., Fernandes-Ferreira, M., and Pereira-Wilson, C.

The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats.Lima, C. F., Azevedo, M.

F., Araujo, R., Fernandes-Ferreira, M., and Pereira-Wilson, C. Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?Lima, C. F., Fernandes-Ferreira, M., and Pereira-Wilson, C.

Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice.Chem Biol Interact.Bone Marrow Transplant.Masuda, T., Inaba, Y., Maekawa, T., Takeda, Y., Tamura, H., and Yamaguchi, H. Recovery mechanism of the antioxidant activity from carnosic acid quinone, an oxidized sage and rosemary antioxidant.Mayer, B., Baggio, C. H., Freitas, C.

S., dos Santos, A. C., Twardowschy, A., Horst, H., Pizzolatti, M. G., Micke, G. A., Heller, M., dos Santos, E.

P., Otuki, M. F., and Marques, M. C. Gastroprotective constituents of Salvia officinalis L.

Fitoterapia 2009;80(7):421-426.Mayer, E., Gescheidt-Shoshany, H., and Weltfriend, S. Allergic contact dermatitis caused by Salvia officinalis extract.Muhlbauer, R.

C., Lozano, A., Palacio, S., Reinli, A., and Felix, R. Common herbs, essential oils, and monoterpenes potently modulate bone metabolism.Plant Physiol 2003;131(4):1816-1825.Nolkemper, S., Reichling, J., Stintzing, F.

C., Carle, R., and Schnitzler, P. Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro.Oboh, G. and Henle, T. Antioxidant and inhibitory effects of aqueous extracts of Salvia officinalis leaves on pro-oxidant-induced lipid peroxidation in brain and liver in vitro.J Med Food 2009;12(1):77-84.Oniga, I., Parvu, A. E., Toiu, A., and Benedec, D. Effects of Salvia officinalis L.

extract on experimental acute inflammation.Orhan, I. and Aslan, M. Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants.Activity of essential oils and individual components against acetyl- and butyrylcholinesterase.Pavela, R. Insecticidal activity of certain medicinal plants.Medicinal plants and dementia therapy: herbal hopes for brain aging?Perry, E.

K., Pickering, A. T., Wang, W.

W., Houghton, P. J., and Perry, N. S. Medicinal plants and Alzheimer's disease: from ethnobotany to phytotherapy.Perry, E. K., Pickering, A. T., Wang, W.

W., Houghton, P., and Perry, N. S.

Medicinal plants and Alzheimer's disease: Integrating ethnobotanical and contemporary scientific evidence.Perry, N. S., Houghton, P.

J., Theobald, A., Jenner, P., and Perry, E. K.

In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes.Perry, N., Court, G., Bidet, N., Court, J., and Perry, E. European herbs with cholinergic activities: Potential in dementia.Eur J Clin Pharmacol 1999;55(2):95-100.Rau, O., Wurglics, M., Paulke, A., Zitzkowski, J., Meindl, N., Bock, A., Dingermann, T., Abdel-Tawab, M., and Schubert-Zsilavecz, M. Carnosic Acid and Carnosol, Phenolic Diterpene Compounds of the Labiate Herbs Rosemary and Sage, are Activators of the Human Peroxisome Proliferator-Activated Receptor Gamma.A., Azevedo, M.

F., Lima, C. F., Fernandes-Ferreira, M., and Pereira-Wilson, C. Sage tea drinking improves lipid profile and antioxidant defences in humans.Savelev, S.

U., Okello, E. J., and Perry, E. K.

Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents.Savelev, S., Okello, E., Perry, N. S.

L., Wilkins, R. M., and Perry, E. K.

Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil.B., Tildesley, N. T., Ballard, C. G., Wesnes, K.

A., Tasker, A., Perry, E. K., and Kennedy, D. O.An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers.Tildesley, N. T., Kennedy, D. O., Perry, E. K., Ballard, C.

G., Wesnes, K. A., and Scholey, A.Vujosevic, M. and Blagojevic, J.

Antimutagenic effects of extracts from sage (Salvia officinalis) in mammalian system in vivo.Vukovic-Gacic, B., Simic, D., Knezevic-Vukcevic, J., and Djarmati, Z. Antimutagenic effect of sage (Salvia officinalis L.).Xavier, C. P., Lima, C.

F., Fernandes-Ferreira, M., and Pereira-Wilson, C. Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway.Nutr Cancer 2009;61(4):564-571.Yu, Y. M., Lin, H.

C., and Chang, W. C. Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9.Zuskin, E., Kanceljak, B., Skuric, Z., and Ivankovic, D. Immunological and respiratory changes in tea workers.Zuskin, E., Kanceljak, B., Witek, T. J., Jr., and Schachter, E. N.

Acute effects of herbal tea dust extracts on lung function.Akhondzadeh S, Noroozian M, Mohammadi M, et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial.J Clin Pharm Ther 2003;28:53-9.Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro.J Agric Food Chem 2000;48:849-52..

View abstract.In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products.Phytomedicine 2003;10:334-42.. View abstract.J Tradit Complement Med.Controlled clinical trial.Complement Ther Med.Br Med J (Clin Res Ed) 1981;282:1823-4.Millet Y, Jouglard J, Steinmetz MD, et al.Toxicity of some essential plant oils.Clinical and experimental study.Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease.Perry NB, Anderson RE, Brennan NJ, et al.Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites.J Agric Food Chem 1999;47:2048-54.. View abstract.Perry NS, Bollen C, Perry EK, Ballard C.

Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial.Pharmacol Biochem Behav 2003;75:651-9.. View abstract.Cancer Res 1997;57:225-8.Eur.J Med Res 9-1-2009;14:406-12.Pharmacol Biochem Behav 2003;75:669-74.. View abstract.Acta Physiol Pharmacol (Bulg) 1984;10:13-20.J Family Med Prim Care. .

Menopause

Some women only have occasional hot flushes that do not really bother them, while others can have many a day and find them uncomfortable, disruptive and embarrassing.They can happen without warning throughout the day and night, but can also be triggered by: eating spicy foods.But you should talk to your GP if you're having other symptoms as well, such as feeling generally unwell, fatigue, weakness, weight loss or diarrhoea.Women often describe a hot flush as a creeping feeling of intense warmth that quickly spreads across your whole body and face.The most effective treatment for hot flushes is hormone replacement therapy (HRT), which usually completely gets rid of them.if you feel a flush coming on, spray your face with cool water or use a cold gel pack (available from pharmacies).if medicine is causing your hot flushes, talk to your doctor about other ways you can take it to avoid this side effect. .

How sage can help with night sweats and hot flushes

For generations, sage preparations have been used to support menopausal health, with a particular focus on reducing the frequency and severity of hot flushes.Here, we uncover how sage may be a helpful treatment for night sweats and hot flushes in menopause.What does sage do for menopause?Experts believe sage has mild phytoestrogenic properties (1).Phytoestrogens are plant-based compounds that naturally mimic oestrogen in the body.In a 2011 study, researchers evaluated the efficacy and safety of using sage to support the reduction of hot flushes by giving a group of women a sage preparation in tablet form for eight weeks (2).A 2016 clinical study conducted on 100 menopausal women complaining of hot flushes reported similar findings (3).At the end of the trial, the frequency, duration, and intensity of hot flushes and night sweats substantially reduced in the sage group compared to the control.As with the previous studies, researchers observed that sage was an effective treatment to reduce hot flushes (4).What is the best way to take sage?It should be noted that only sage supplementation has been studied for its role in menopausal symptoms.What are the side effects of sage?First time proof of sage’s tolerability and efficacy in menopausal women with hot flushes.International Journal of Medical Research & Health Sciences. .

Health Benefits of Sage during Menopause

Sage is known to help treat common symptoms of the menopause such as hot flushes and overheating.Common Sage also known as Salvia officinalis, is a well known culinary herb that can add flavour to many dishes.Sage is not only used for its flavour and health benefits, but is also used as a natural cleaning agent, and can also be burned to improve the air quality and fragrance of a room.Greeks considered garden sage to be “good for helping diminution of senses and loss of memory”.In the first medieval medical school in Salerno (Italy), the locally grown species of sage was considered a sacred herb.Sage, like plants from the same family such as rosemary or lemon balm, is a natural source of flavonoids and polyphenolic compounds.Carnosic and rosmarinic acid are present in high concentrations in sage extract, and are known for their strong antioxidant properties.In a small open multicentre human study with 71 menopausal women, sage was found to be effective in reducing hot flushes after 8 weeks4.In a more recent study in Iran, consumption of 300mg of sage extract decreased the severity of hot flushes and night sweats after 3 months, in comparison to the placebo group.It has been a longstanding belief that sage extract has anti-sweating properties, although most of the evidence for this comes from historical use and from open studies done mainly in the 1930s8.Culpepper’s ‘Complete Herbal’ notes in the 17th century state that ‘It also heals the memory, warning and quickening the senses’.Sage extract has been shown in cell studies to block the action of acetylcholinesterase (AchE), an enzyme that destroys the neurotransmitter acetylcholine and therefore reduces its levels.Acetylcholine is an essential neurotransmitter, which plays an important role in cognitive function such as memory and learning.Oxidative stress has been shown to be implicated in the general process of aging and tissue damage, especially in the brain.In a study of 20 healthy elderly adults, volunteers that took sage showed significant improvement in memory performance and accuracy tests in comparison to a placebo11.Studies have shown that sage oil can help lower blood sugar levels and obesity markers12.Unfortunately there have been an insufficient number of human studies carried out to suggest sage could be recommended as a diabetes treatment.Sage has antimicrobial properties, and it has been suggested that it could be a natural remedy to help with mouth and teeth issues like dental cavities.In a study of school girls, the group that used a sage mouthwash had significantly reduced the number of Streptococcus mutans, one of the bacteria that causes plaque13.Nevertheless, drinking sage leaf tea in excessive amounts can cause tachycardia (an abnormally rapid heart rate), vertigo and seizures.High quality products will be standardised against rosmarinic acid, one of the active compounds in sage that is easily identified in analysis.First time proof of sage’s tolerability and efficacy in menopausal women with hot flushes.Zeidabadi A, Yazdanpanahi Z, Dabbaghmanesh MH, Sasani MR, Emamhoreishi M, Akbarzadeh M. The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women.Tober C, Schoop R.

Modulation of neurological pathways by Salvia officinalis and its dependence on manufacturing process and plant parts used.Dadfar F, Bamdad K. The effect of Saliva officinalis extract on the menopausal symptoms in postmenopausal women: an RCT.Schley AB, Tildesley NT, Ballard CG, Wesnes KA, Tasker A, Perry EK, Kennedy DO.An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers.Belhadj S, Hentati O, Hammami M, Ben Hadj A, Boudawara T, Dammak M, Zouari S, El Feki A.

Metabolic impairments and tissue disorders in alloxan-induced diabetic rats are alleviated by salvia officinalis L. essential oil.Beheshti-Rouy M, Azarsina M, Rezaie-Soufi L, Alikhani MY, Roshanaie G, Komaki S. The antibacterial effect of sage extract (Salvia officinalis) mouthwash against Streptococcus mutans in dental plaque: a randomized clinical trial.Edwards S, Rocha I, Williamson EM, Heinrich M. Phytopharmacy: an evidence-based guide to herbal medicinal products.Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L). .

Sage: Health Benefits, Side Effects, Uses, Dose & Precautions

References.Abdel-Fatah, M. K., El-Hawa, M. A., Samia, E. M., Rabie, G., and Amer, A.

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and Isik, I.Croteau, R. and Purkett, P. T. Geranyl pyrophosphate synthase: characterization of the enzyme and evidence that this chain-length specific prenyltransferase is associated with monoterpene biosynthesis in sage (Salvia officinalis).Biochemistry 12-3-1985;24(25):7077-7085.Biochemistry 8-25-1987;26(17):5383-5389.Croteau, R., El Bialy, H., and Dehal, S.

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N., Affara, N. I., and Gali-Muhtasib, H. U.Seasonal changes in the composition of the essential oil extract of east mediterranean sage (Salvia libanotica) and its toxicity in mice.Toxicon 2001;39(10):1601-1605.Pharmazeutische Zeitung 1982;127:111-114.The protective effect of the Mediterranean diet on lung cancer.Nutr Cancer 2003;46(1):30-37.Gambliel, H. and Croteau, R.

Biosynthesis of (+/-)-alpha-pinene and (-)-beta-pinene from geranyl pyrophosphate by a soluble enzyme system from sage (Salvia officinalis).Grzunov, K., Mastelic, J., and Ruzic, N. Identification of aglycones of b-D-glucosides from the leaves of Dalmatian sage (Salvia officinalis).Acta Pharm Jugosl 1985;35:175-179.Part II.Int J Food Microbiol.Hellum, B. H. and Nilsen, O. G. In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products.Basic Clin Pharmacol Toxicol.Hohmann, J., Zupko, I., Redei, D., Csanyi, M., Falkay, G., Mathe, I., and Janicsak, G.

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B., Seabra, R. M., Fernandes-Ferreira, M., and Pereira-Wilson, C. The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats.Lima, C. F., Azevedo, M. F., Araujo, R., Fernandes-Ferreira, M., and Pereira-Wilson, C. Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?Lima, C.

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C., Fernandes-Ferreira, M., and Pereira-Wilson, C. Evaluation of toxic/protective effects of the essential oil of Salvia officinalis on freshly isolated rat hepatocytes.Toxicol.In Vitro 2004;18(4):457-465.Lima, C. F., Fernandes-Ferreira, M., and Pereira-Wilson, C.

Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice.Chem Biol Interact.Bone Marrow Transplant.Lu, Y. and Foo, L.

Y. Rosmarinic acid derivatives from Salvia officinalis.Mantle, D., Pickering, A. T., and Perry, E.

K. Medicinal plant extracts for the treatment of dementia: A review of their pharmacology, efficacy and tolerability.Masterova, I., Misikova, E., Sirotkova, L., Vaverkova, S., and Ubik, K.

[Royleanones in the roots of Salvia officinalis L. of domestic provenance and their antimicrobial activity].Masuda, T., Inaba, Y., Maekawa, T., Takeda, Y., Tamura, H., and Yamaguchi, H.

Recovery mechanism of the antioxidant activity from carnosic acid quinone, an oxidized sage and rosemary antioxidant.Mayer, B., Baggio, C. H., Freitas, C. S., dos Santos, A. C., Twardowschy, A., Horst, H., Pizzolatti, M. G., Micke, G. A., Heller, M., dos Santos, E.

P., Otuki, M. F., and Marques, M. C. Gastroprotective constituents of Salvia officinalis L. Fitoterapia 2009;80(7):421-426.Mayer, E., Gescheidt-Shoshany, H., and Weltfriend, S. Allergic contact dermatitis caused by Salvia officinalis extract.McGeady, P.

and Croteau, R. Isolation and characterization of an active-site peptide from a monoterpene cyclase labeled with a mechanism-based inhibitor.Study of the toxicity of essential vegetable oils: hyssop oil and sage oil.Miura, K., Kikuzaki, H., and Nakatani, N. Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method.Muhlbauer, R. C., Lozano, A., Palacio, S., Reinli, A., and Felix, R. Common herbs, essential oils, and monoterpenes potently modulate bone metabolism.Herbal medicines for menopausal symptoms.Drug and Therapeutics Bulletin 2009;47:2-6.Nolkemper, S., Reichling, J., Stintzing, F. C., Carle, R., and Schnitzler, P.

Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro.Oboh, G. and Henle, T.

Antioxidant and inhibitory effects of aqueous extracts of Salvia officinalis leaves on pro-oxidant-induced lipid peroxidation in brain and liver in vitro.J Med Food 2009;12(1):77-84.Orhan, I. and Aslan, M.

Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants.Activity of essential oils and individual components against acetyl- and butyrylcholinesterase.Pavela, R. Insecticidal activity of certain medicinal plants.Cultivated Plants.Essential oils from plants belonging to the genus Salvia.Medicinal plants and dementia therapy: herbal hopes for brain aging?Perry, E.

K., Pickering, A. T., Wang, W. W., Houghton, P. J., and Perry, N. S. Medicinal plants and Alzheimer's disease: from ethnobotany to phytotherapy.J Pharm Pharmacol 1999;51(5):527-534.Perry, E.

K., Pickering, A. T., Wang, W.

W., Houghton, P., and Perry, N. S. Medicinal plants and Alzheimer's disease: Integrating ethnobotanical and contemporary scientific evidence.Perry, N. S., Houghton, P. J., Sampson, J., Theobald, A. E., Hart, S., Lis-Balchin, M., Hoult, J.

R., Evans, P., Jenner, P., Milligan, S., and Perry, E. K.

In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's disease.J Pharm Pharmacol 2001;53(10):1347-1356.Perry, N. S., Houghton, P. J., Theobald, A., Jenner, P., and Perry, E.

K. In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes.J Pharm Pharmacol 2000;52(7):895-902.Pitarevic, I., Kuftinec, J., Blazevic, N., and Kustrak, D.

Seasonal variation of essential oil yield and composition of Dalmatian sage, Salvia officinalis.A., Widrlechner, M. P., Reddy, M. B., and Hendrich, S. Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers.Contribution to quantity and composition assays of essential oil in dalmatian sage (Salvia officinalis L.).Acta Pharm Jugosl 1985;35:121-125.J Med Chem 1976;19:1054-1057.In vitro antimicrobial activity of essential oils from aromatic plants against selected foodborne pathogens.Comparison of conventional and ultrasonically assisted extractions of pharmaceutically active compounds from Salvia officinalis.Santos-Gomes, P. C. and Fernandes-Ferreira, M.

Essential oils produced by in vitro shoots of sage (Salvia officinalis L.).Santos-Gomes, P. C.

and Fernandes-Ferreira, M. Organ- and season-dependent variation in the essential oil composition of Salvia officinalis L. cultivated at two different sites.Santos-Gomes, P. C., Seabra, R. M., Andrade, P. B., and Fernandes-Ferreira, M.

Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.).Savelev, S. U., Okello, E.

J., and Perry, E. K. Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents.Savelev, S., Okello, E., Perry, N. S. L., Wilkins, R. M., and Perry, E.

K. Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil.Schmidt, Z., Pekic, B., and Karuza-Stojakovic, L. Examination of essential oil extracted from sage leaves (Salviae Folium).Comparative in vitro study on the anti-herpetic effect of phytochemically characterized aqueous and ethanolic extracts of Salvia officinalis grown at two different locations.B., Tildesley, N. T., Ballard, C. G., Wesnes, K. A., Tasker, A., Perry, E.

K., and Kennedy, D. O.An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers.Sellerberg, U. Sage: classic under medicinal plants.Gas chromatographic determination of main active substances in infusions of essential oil plant raw material.[The results of sanitary chemical research into denture base materials coated with components from essential-oil plants].Die Pharmazie 1993;48:938-940.Tildesley, N. T., Kennedy, D.

O., Perry, E. K., Ballard, C.

G., Wesnes, K. A., and Scholey, A.New York: Pharmaceutical Products Press;1993.Vaverkova, S.

and Holla, M. Qualitative properties of three species of the genus Salvia.Content and composition of the essential oil.Part 2: Content and composition of the essential oil from Salvia officinal is L.

after application of Afalon 50 WP.Vaverkova, S., Holla, M., Tekel, J., and Kucerova, M. Content and quality of the ethereal oil from Salvia officinalis L.

after the application of Patoran 50 WP.Analysis of sage oils by GC-MS data bank Salvia officinalis L. and Salvia lavendulaefolia Vahl.Acta Pharm Jugosl 1977;27:139-142.Wake, G., Court, J., Pickering, A., Lewis, R., Wilkins, R., and Perry, E. CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory.Isolation and structure elucidation of two new glycosides from sage.J Agric Food Chem 2000;48:235-238.Wang, M., Shao, Y., Li, J., Zhu, N., Rangarajan, M., LaVoie, E. J., and Ho, C.

T. Antioxidative phenolic glycosides from sage (Salvia officinalis).Wise, M. L., Savage, T.

J., Katahira, E., and Croteau, R. Monoterpene synthases from common sage (Salvia officinalis).Wu, T.

Y., Chen, C. P., and Jinn, T. R. Traditional Chinese medicines and Alzheimer's disease.Nutr Cancer 2009;61(4):564-571.Yu, Y.

M., Lin, H. C., and Chang, W. C. Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9.Zupko, I., Hohmann, J., Redei, D., Falkay, G., Janicsak, G., and Mathe, I. Antioxidant activity of leaves of Salvia species in enzyme-dependent and enzyme-independent systems of lipid peroxidation and their phenolic constituents.Zuskin, E., Kanceljak, B., Witek, T. J., Jr., and Schachter, E.

N. Acute effects of herbal tea dust extracts on lung function.J Clin Pharm Ther 2003;28:53-9.First time proof of sage's tolerability and efficacy in menopausal women with hot flushes.Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro.J Agric Food Chem 2000;48:849-52..

View abstract.Ann Intern Med 1990;113:82-3.J Agric Food Chem 2000;48:2576-81.Part 182 -- Substances Generally Recognized As Safe.In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products.Phytomedicine 2003;10:334-42.. View abstract.The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol.Basic Clin Pharmacol Toxicol.Br Med J (Clin Res Ed) 1981;282:1823-4.Millet Y, Jouglard J, Steinmetz MD, et al.Toxicity of some essential plant oils.Clinical and experimental study.Perry NB, Anderson RE, Brennan NJ, et al.Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites.J Agric Food Chem 1999;47:2048-54..

View abstract.Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial.Pharmacol Biochem Behav 2003;75:651-9.. View abstract.Cancer Res 1997;57:225-8.Schapowal A, Berger D, Klein P, et al.

Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial.Eur.J Med Res 9-1-2009;14:406-12.Pharmacol Biochem Behav 2003;75:669-74.. View abstract.Experimental pharmacological study of three species from genus Salvia.Acta Physiol Pharmacol (Bulg) 1984;10:13-20.

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Could Sage Be The Answer To Peri-menopausal Hot Flashes?

A hot flash is a sudden feeling of intense heat or warmth that seems to come from nowhere, and quickly spreads throughout the body, in particular the face, neck and chest.Although not considered to pose any inherent risks to health, hot flashes can be incredibly uncomfortable for the sufferer, interfering with normal daily functions and causing increased stress, lowered mood and poorer sleep quality.The sage plant, a member of the Lamiaceae family native to Mediterranean Europe, has a long history of traditional use in supporting a reduction in hot flashes, night sweats and associated climacteric complaints in menopausal women.A 2011 study involving 71 women across 8 treatment centres in Switzerland was carried out to assess the safety and efficacy of sage as a support to reduce the frequency and severity of menopausal hot flashes.Duration, intensity, and frequency of hot flashes and night sweats were also evaluated every week, and the two groups were compared in terms of these variables.The researchers concluded that extracts of sage significantly reduced the frequency, severity, and duration of treatment of hot flashes, night sweats, and other menopausal symptoms and can be considered as a safe and effective alternative therapy for the individuals who are not able to use HRT.2.Participants received a 100mg capsule of sage extract daily for 4 weeks and the severity of symptoms were compared before and after the 4-week supplementation period.Results showed significant differences in the severity of hot flashes, night sweats, panic, fatigue and concentration following supplementation with sage extract.When considering supplementation with this valuable herb it’s important to note that fresh sage extracts are regarded as superior in terms of efficacy. .

First time proof of sage's tolerability and efficacy in menopausal

This trial aimed to assess the tolerability and efficacy of a fresh sage preparation in treating hot flushes and other menopausal complaints.In an open, multicenter clinical trial conducted in eight practices in Switzerland, 71 patients (intent-to-treat population [ITT], n=69; with a mean age of 56.4±4.7 years, menopausal for at least 12 months, and with at least five flushes daily) were recruited and treated with a once-daily tablet of fresh sage leaves for 8 weeks after an introductory baseline week.Other variables included assessment of the Menopause Rating Scale (MRS) by the treating physician at baseline and after 2 months of therapy. .

Sage: Health Benefits, Side Effects, and Interactions

In recent years, scientists have looked into how effective sage or sage extracts are in preventing or treating common medical conditions.There are numerous varieties of sage used for culinary and medical purposes, the most common of which is Salvia officinalis (also known as common sage).What Is Sage Used For?Anti-Inflammatory Effects.Sage may be beneficial in providing relief for inflammatory conditions such as sore throats and sunburn.Improved Cholesterol.Total cholesterol levels were lowered by 16 to 20 percent.Moreover, while the activation of PPAR gamma is associated with improved blood sugar, this effect has not been seen when taking sage or a sage extract.As far-fetched as it may seem, there is evidence that sage can improve memory and information processing, even in people with Alzheimer's disease.Other studies included in the review consistently showed improvements in short-term memory, alertness, and speed recall.Perhaps the most controversial claim by alternative practitioners is that sage can help prevent cancer.Within this context, scientists have been able to prove that components of S. officinalis or S. lavandulaefolia (including carnosol, rosmarinic acid, and ursolic acid) can inhibit the growth of cancer cells in test tubes, including breast cancer, colon cancer, chronic myeloid leukemia, prostate cancer, liver cancer, and small cell lung carcinoma.While test tube results infrequently translate to humans, a 2013 review of studies reported that rosmarinic acid given daily to mice was able to prevent skin cancer as well as bone metastasis from breast cancer.Possible Side Effects.The excessive use of sage in people on diabetes medications can also trigger a potentially severe drop in blood sugar, leading to hypoglycemia.When used for health purposes, sage can be found in oral extracts, gel caps, and capsule formulations as well as topical creams and ointments.There is no standardized dosage, but doses of up to 1,000 milligrams per day are generally considered safe and well tolerated. .

3 Ways To Cool Hot Flashes

Summer can be a really hellish time when you're coping with hot flashes and night sweats.I'd take three or four slow breaths whenever I felt the heat coming on, and the hot flash just faded away.Practicing calming meditation also helps—scientists are finding that stress hormones aggravate menopausal symptoms.Sip some sage. .

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